World Wrestling Entertainment presented final elimination chamber match between Rey Mysterio and Dolph Ziggler at WWE Smackdown edition on February 5, 2010. Actually, these two wrestling superstars wrestled for Intercontinental Championship title several times. However, they once again challenged in this wrestling edition.

Actually, Dolph Ziggler failed to win 30 Men battle royal rumble. Similarly, Rey Mysterio lost a golden opportunity to dead man the undertaker in a world heavyweight championship match on same night. However, they both decided to face The Undertaker at Elimination Chamber 2010 in Smackdown elimination chamber match.

Dolph Ziggler gave excellent starting to this wrestling match by dominating the Rey Mysterio. However, Rey Mysterio tried to control him but Dolph Ziggler continued his domination by concentrating on this match. However, Rey Mysterio defeated Dolph Ziggler surprisingly through pin fall.